People with a high family risk for depression had less brain matter on the right side, similar to that seen with Alzheimer’s disease, according to U.S. researchers.

The researchers found with brain scans that there was a 28% thinning in the right cortex (the outer layer of the brain) in those with a family history of depression.

The findings were based on imaging studies of 131 people aged 6 to 54 with a family history

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